Genomic, Ancestry & Admixture Dashboard • GRCh37 VCF Analysis
| Ancestral Stream | Share | Historical Period, Archeology & Evolutionary Context |
|---|---|---|
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Indus Valley Civilization South Asian Bronze Age |
A composite IVC-related proxy carrying both Iranian-related farmer ancestry and indigenous South Asian ancestry.
🏺 Important: This component already contains AASI-related ancestry; it should not be treated as “pure Iranian farmer.”
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AASI (Onge Proxy) Indigenous South Asian |
Additional AASI-related ancestry outside the ancestry already embedded in the IVC proxy.
🏹 Interpretation: A statistical deep-ancestry proxy, not a sampled unmixed AASI genome.
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Central Steppe Bronze Age Herders |
Steppe-related Bronze Age ancestry represented by Central Steppe reference populations.
🐎 Scope: This supports population-level Steppe-related ancestry, but does not determine the sample’s Y-chromosome haplogroup.
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| Rank | Population Reference | Distance | Detailed Regional Context & Significance |
|---|---|---|---|
| #1 | Meena Rajasthan | 2.345 |
Closest modern reference; places the sample toward northern/western South Asia.
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| #2 | Punjabi Lahore | 2.479 |
Strong northwestern South Asian affinity, independently consistent with local AADR PCA.
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| #3 | Brahmin Andhra Pradesh | 2.516 |
A nearby South Asian reference reflecting a similar broad ancestry balance.
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| #4 | Gujarati B | 2.608 |
Supports western Indian affinity within the broader South Asian continuum.
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| #5 | Brahmin Tamil Nadu | 2.645 |
Another close reference; modern labels are comparison anchors, not identity assignments.
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| Rank | Ancient Reference | Distance | Interpretation |
|---|---|---|---|
| #1 | Medieval Indian Roopkund | 4.116 |
Closest ancient reference in the authenticated list.
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| #2 | Gandhara Indo-Greek | 4.674 |
Supports affinity to ancient populations from the northwestern subcontinent.
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| #3 | Indus Valley Civilization | 5.224 |
Directly reflects the major IVC-related ancestry signal.
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| #4 | Gandhara Mauryan | 5.846 |
A second close Gandhara-period comparison.
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Use sleep response as the guide: CYP1A2 markers have modest predictive value and are affected by smoking, medication and other factors. If caffeine disrupts sleep, reduce the dose or move it earlier; the genotype alone does not justify a strict cutoff.
Standard nutrition guidance applies: The reported MTHFR C677T call does not indicate the common reduced-function genotype, but it neither guarantees “100% function” nor determines supplement need. Use diet, labs and clinical advice.
No prescriptive cognitive claim: COMT Val/Met is real in the VCF, but one SNP cannot establish an “optimal” dopamine level or ideal work-block length. Choose focus routines from observed performance.
Small population-level tendency: ACTN3 577X/X eliminates functional alpha-actinin-3 and is associated with a modest endurance shift in some studies. It does not predict individual athletic ability; train strength and endurance according to goals and response.
| Trait / Biological Pathway | Gene & Genotype | Detailed Interpretation & Real-World Phenotype Impact |
|---|---|---|
| Dopamine & Stress Response |
COMT Val158Met rs4680: G / A |
Val/Met genotype
Carries one Val and one Met allele. COMT activity differs on average by genotype, but “warrior/worrier” labels oversimplify a complex phenotype.
⚡ Limit: This single marker cannot predict focus, memory, resilience or response to stress for an individual.
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| Caffeine Clearance Rate |
CYP1A2 163A>C rs762551: C / C |
Slow Caffeine Metabolizer
This commonly studied marker is associated with caffeine metabolism, but genotype-to-phenotype mapping varies by assay strand, environment and other genes.
☕ Limit: It does not establish a personal 6–8 hour half-life or a universal 2 PM cutoff. Observed sleep response is more actionable.
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| Caffeine Sensitivity / Anxiety |
A2AR Adenosine Receptor rs5751876: T / C |
Moderate Caffeine Sensitivity
Carries one copy of the adenosine A2A receptor variant associated with heightened central nervous system sensitivity to caffeine.
⚡ Limit: Jitters and alertness depend strongly on dose, tolerance, sleep and other factors; this SNP is not determinative.
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| Satiety & Appetite Control |
FTO Fat-Mass Gene rs9939609: T / T |
Protective Genotype (Low Risk)
Homozygous for the protective
T allele at the FTO locus, maintaining normal hypothalamic satiety signaling via leptin and ghrelin.
🥗 Limit: This is one small-effect association and cannot predict appetite control, eating behavior or body weight.
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| Predicted Blood Group |
ABO Glycosyltransferase rs8176719: 0 / 0 (D/D) |
Predicted Type O Blood
Homozygous for the 261delG frameshift deletion in exon 6 of the ABO gene, which completely inactivates A and B glycosyltransferase enzymes.
🩸 Limit: The deletion call has low genotype quality and ABO type also depends on other alleles. Treat Type O as tentative and confirm with a blood-typing test.
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| Bitter Taste Sensitivity |
TAS2R38 Taste Receptor rs713598: C / C |
Moderate Bitter Taster
Carries the
AVI / AVV taste receptor haplotype, providing balanced sensitivity to glucosinolates and PTC bitter compounds.
🥦 Limit: TAS2R38 taste phenotype requires a correctly phased multi-SNP haplotype and does not reliably predict preferences from this marker alone.
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| Sleep Schedule & Chronotype |
CLOCK Gene rs1801260: A / G |
Flexible Circadian Rhythm
Heterozygous for the 3111T>C clock gene variant that regulates suprachiasmatic nucleus circadian timing.
🌙 Limit: One CLOCK association cannot establish chronotype or adaptability; sleep history and behavior are much stronger evidence.
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| Endogenous Pain Threshold |
OPRM1 Opioid Receptor rs1799971: A / G |
Association is inconsistent
Carries one copy of the
118G variant in the mu-opioid receptor gene (OPRM1).
🩹 Limit: Published effects vary by population and endpoint. Do not infer an individual pain threshold or medication response from this SNP.
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| Lactose Digestion |
MCM6 / LCT Gene rs4988235: A / A |
Lactase Persistence (Tolerant)
Homozygous for the Eurasian
-13910*T (A) persistence enhancer mutation upstream of the LCT lactase gene.
🥛 Interpretation: This genotype supports European-associated lactase persistence, but symptoms still depend on dose, gut health and ancestry-specific variants.
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| Muscle Performance Profile |
ACTN3 Alpha-Actinin-3 rs1815739: T / T |
ACTN3 deficiency; modest endurance association
Homozygous for the
577X null allele (T/T), leading to alpha-actinin-3 deficiency in fast-twitch skeletal muscle fibers.
🏋️ Limit: Population studies show a modest shift toward endurance phenotypes, not guaranteed endurance, fatigue resistance or recovery. Training history dominates performance.
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| Alcohol Metabolism (Flush) |
ALDH2 Dehydrogenase rs671: G / G |
No ALDH2*2 allele at rs671
Homozygous for the wild-type ALDH2*1 allele, producing fully functional aldehyde dehydrogenase enzymes.
🍷 Limit: This lowers the likelihood of classic ALDH2*2 flushing but does not make alcohol safe or rule out symptoms from other causes.
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| COVID-19 Severity Marker |
LZTFL1 Introgressed Locus rs35044562: absent from VCF |
No result
The claimed genotype could not be found in the supplied VCF and is therefore withdrawn.
🛡️ Limit: Do not infer COVID-19 risk from this report. Disease severity is multifactorial and this marker was not genotyped here.
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| Folate Metabolism Pathway |
MTHFR Reductase rs1801133: G / G |
Common non-677T genotype
The VCF call is consistent with no copies of the common C677T reduced-function allele.
🌿 Limit: This does not guarantee optimal folate metabolism or determine supplement requirements; diet, other variants and laboratory values matter.
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